Brock Purdy’s three interceptions overshadow great games from Christian McCaffrey, George Kittle, and the 49ers’ defense.

The Carolina Panthers face the San Francisco 49ers on Monday, Nov. 24, 2025 at Levi’s Stadium in Santa Clara, California.

The Panthers are unable to punch it in for a touchdown, as running back Chuba Hubbard is stopped on a short pass on third-and-goal from the Niners' 4-yard line. Carolina settles for a 25-yard field goal from kicker Ryan Fitzgerald.

This will surely put them over the top. The Carolina Panthers have announced a pair of moves going into tonight's game with the San Francisco 49ers on ESPN's presentation of Monday Night Football. The Panthers are 6-5 and have a chane to take first place in the NFC South thanks to Tampa's loss to the Los Angeles Rams last night.

Carolina is coming off a huge Week 11 win over Atlanta in which quarterback Bryce Young had a career day, passing for 448 yards and three touchdowns in the Panthers' 30-27 overtime victory. Rookie wideout Tetairoa McMillan also set career highs with eight catches for 130 yards and two touchdowns.

The San Francisco 49ers are getting ready to take on the Carolina Panthers on Monday Night Football this week, looking to stack consecutive wins for the first time since Week 3. San Francisco is coming off a 41-22 win over the Arizona Cardinals in a game that they dominated from the start,

Oct 9, 2022; Charlotte, North Carolina, USA; San Francisco 49ers running back Jeff Wilson Jr. (22) runs for yardage pursued by Carolina Panthers cornerback Jaycee Horn (8) during the first quarter at Bank of America Stadium. / Jim Dedmon-Imagn Images

Our best Panthers vs. 49ers player prop bets tonight include Christian McCaffrey and George Kittle to put up big numbers.