The Panthers hit the road to take on the 49ers on Monday Night Football. The 49ers/Panthers game starts at 8:15 p.m. ET on ESPN. Yes! Peyton and Eli will be on ESPN2 for tonight’s 49ers/Panthers matchup.

Teams looking to stay in the mix in their respective divisions clash when the Carolina Panthers battle the San Francisco 49ers on 'Monday Night Football.' Carolina is coming off a 30-27 overtime win over the Atlanta Falcons,

Take a look at key stats from the San Francisco 49ers Week 12 "Monday Night Football" matchup vs. the Carolina Panthers.

On Monday night, the favored San Francisco 49ers survived a mistake-filled performance against the Carolina Panthers on Monday Night Football, avoiding a primetime upset.

Jennings, who has 32 catches for 378 yards and three touchdowns this season, could be in trouble with the NFL for his actions. The league will review the incident, which could be classified as unsportsmanlike conduct, a violation that carries a $14,491 fine.

SportsLine's AI Model has simulated 49ers vs. Panthers on 'Monday Night Football' and revealed an NFL SGP that pays over 6-1