NFL Week 13 odds, picks, predictions, TV channel, streaming information for the Sunday football game between Buffalo Bills and Pittsburgh Steelers.

The Kansas City Chiefs, Buffalo Bills, Detroit Lions and Dallas Cowboys are all flirting with the possibility of missing the 2025 NFL playoffs; could the Baltimore Ravens and Pittsburgh Steelers both sneak in from the AFC North?

Next on the Buffalo Bills' schedule is another grueling road trip, this one to Pittsburgh to play the Steelers.

The Bills are bringing back a familiar face. Buffalo has signed former first round pick Shaq Lawson to their practice squad, marking his third stint with the team, Mike Garafolo of the NFL Network reported on Tuesday.

The Buffalo Bills fell short to the Houston Texans on "Thursday Night Football," dropping their 2025 record to 7-4. It didn't take long for fans to assign blame for this upset loss. Houston's defense was dominant all night long against Buffalo,

Bills: A shocking upset loss to Miami dropped the Bills to 6-3, and they're facing an uphill battle to unseat the Patriots in the AFC East. The Bills fell from +600 to +1000 to win the Super Bowl after Week 10.

The Houston Texans (5-5) will play the Buffalo Bills (7-3) at NRG Stadium on Thursday. Buffalo is 5.5-point favorites from Vegas oddsmakers. The betting total is set at 43.5.

Significant movement in the NFL MVP race over the last four weeks has the competition down to two main candidates. Los Angeles Rams quarterback Matthew Stafford and New England Patriots QB Drake Maye have firmly established themselves as the front runners following Week 12.

For Week 13 NFL betting, SportsLine AI has evaluated the NFL odds and provided NFL betting picks for all 16 games. You can only see the AI predictions for the Week 13 NFL schedule here. New users can also target the latest Underdog promo code, good for $100 in bonus entries when you play $5 with the promo code CBSSPORTS2 in select states.

The Buffalo Bills are setting the table for a second-year offensive tackle to return and provided much-needed depth down the season stretch