The Week 12 NFL schedule is headlined by the ever-continuing saga of the Kansas City Chiefs against the AFC South-leading Indianapolis Colts on Nov. 23. Kansas City is 5-5 after losing on a last-second field goal at Denver and returns home in need of a run.

You've seen the model's best bets for Indianapolis Colts vs. Kansas City Chiefs. Now, get against the spread, total and money-line picks for every Week 12 NFL game here, all from the model that's simulated every game 10,000 times.

The Chicago Bears will battle the Pittsburgh Steelers in Week 12. See if the game will be on in your part of the country.

The Cincinnati Bengals won’t activate quarterback Joe Burrow for the Week 12 game against the New England Patriots, according to a new report.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 on a 48-33 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

The Miami Dolphins take back-to-back wins into their Week 12 bye week, giving them a chance to reinforce what has worked over the last two games as they try to make an improbable run through the second half of the 2025 NFL season.

Ken Walker is starting to take over the Seattle backfield by reclaiming the goal line role over Zach Charbonnet. That has happened just in time for a smash spot against the Titans.

The Packers ruled out two players: corner Nate Hobbs (knee) and wide receiver Jayden Reed (foot/shoulder). Reed's 21-day practice window opened Friday as he works back from both foot and collarbone surgeries from Week 2. Hobbs did not practice all week.