Follow along with live updates as the San Francisco 49ers and Carolina Panthers put their playoff hopes on the line in Week 12.

Monday Night Football schedule, TV channel, time, streaming information for Carolina Panthers vs San Francisco 49ers NFL Week 12 game Nov. 24, 2025.

The San Francisco 49ers had a productive offense under coach Kyle Shanahan for a while when the team made the big deal to acquire Christian McCaffrey from Carolina three years ago. The addition of one of the NFL's best dual-threat backs ever elevated that offense to another level that will be on display for the Panthers

A big stretch of games begins for the San Francisco 49ers on Sunday in Arizona against the Cardinals. Here's how to watch their Week 11 showdown.

Playing against the Cardinals, San Francisco 49ers rookie Upton Stout showed off why he earned him the nickname "Hit Man" - but he also has a frightening problem for an NFL cornerback.

That’s not to say this evening’s Monday Night Football game between the 7-4 San Francisco 49ers and 6-5 Carolina Panthers is void of significance for Buffalo’s playoff hopes. You see, if the Panthers win tonight,