The San Francisco 49ers defeated the Indianapolis Colts 48-27 on Monday night, in their fifth straight win. Purdy threw for 295 yards, finishing with a career-high five touchdowns. Christian McCaffrey rushed 21 times for 117 yards, making six catches for 29 yards and two touchdowns.

NFL Week 18 odds, picks, predictions, TV channel, streaming information for Saturday football game between Seattle Seahawks and San Francisco 49ers.

San Francisco 49ers cornerback Deommodore Lenoir discussed the upcoming matchup against the Seattle Seahawks in Week 18 of the 2025 NFL Season.

The Bears totaled 440 yards and found the end zone five times in Sunday night's road battle with the 49ers, but Jauan Jennings' 38-yard touchdown reception late in the fourth quarter gave San Francisco a 42-38 victory at Levi's Stadium.

Week 18 of the NFL season is upon us, which means fantasy football managers are either playing for a championship title, celebrating a championship title or have already been eliminated. For those who have a title on the line, the challenge of setting lineups and finding an edge has only grown since the week before.

A string of stars showed up to support the San Francisco 49ers as they faced off against the Chicago Bears on Sunday, Dec. 28.

The 12-4 49ers have been without star defensive end Nick Bosa and linebacker Fred Warner for most of the season. Star tight end George Kittle has missed time this season and didn't play Sunday.

Sunday’s finale will bookend a season that started with the 49ers in Seattle, eking out a 17-13 victory over the Seahawks as a late Brock Purdy touchdown to Jake Tonges earned them their first win of the season. Seattle has won 11 of its last 13 games to set up this showdown that will determine the NFC West.