The San Francisco 49ers (7-4) will take on the Carolina Panthers (6-5) at Levi Stadium in Santa Clara, California, on Monday, Nov. 24.

Thanks in large part to a stellar defense and a workhorse performance by Christian McCaffrey, the 49ers were able to overcome a bad night by Brock Purdy to defeat Bryce Young and the Panthers on Monday night.

The Panthers hit the road to take on the 49ers on Monday Night Football. The 49ers/Panthers game starts at 8:15 p.m. ET on ESPN. Yes! Peyton and Eli will be on ESPN2 for tonight’s 49ers/Panthers matchup.

With a win tonight, the 49ers’ odds of making the playoffs move from 83 percent from 89 percent in The Athletic’s NFL Playoff Simulator. With the Rams firmly atop the NFC West (and, now, the entire NFC), San Francisco is overwhelmingly likely to make the playoffs as a wild-card team.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 on a 48-33 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Brock Purdy, Christian McCaffrey and the San Francisco 49ers host the Carolina Panthers led by quarterback Bryce Young on Monday Night Football as Week 12 of the NFL season wraps up tonight in this Ba

Brock Purdy played a sloppy first half in Monday night's game against the Panthers, but his team still leads 10-3 at the halftime break.

Teams looking to stay in the mix in their respective divisions clash when the Carolina Panthers battle the San Francisco 49ers on 'Monday Night Football.' Carolina is coming off a 30-27 overtime win over the Atlanta Falcons,

Take a look at key stats from the San Francisco 49ers Week 12 "Monday Night Football" matchup vs. the Carolina Panthers.

Catch Bryce Young and the Panthers (6-5) against Brock Purdy and the 49ers (7-4) at 8:15 p.m. ET on ESPN with streaming options available.

DraftKings offers a $200 bonus if your first bet $5 wager wins and 3 months free NBA League Pass for Carolina vs. San Francisco on Monday Night Football