Together with tobacco, alcohol is the most abundantly consumed noxious compound worldwide. Within the last decade, much knowledge about the pathophysiology of alcohol-related organ damage has been ...

Background Chronic pancreatitis (CP) is a risk factor for pancreatic cancer, with inherited cases conferring a markedly increased risk. The underlying mechanisms driving malignant transformation by CP ...

Colorectal cancer (CRC), a type of cancer that affects the large intestine and rectum, is one of the leading causes of cancer-related deaths worldwide. The mutational landscape of CRC is ...

According to recent estimates, over 140 million people from 50 countries regularly get exposed to arsenic through drinking water. The exposure level significantly exceeds the guideline value (10 μg/L) ...

During carcinogenesis, the HPV genome integrates into the host genome, often disrupting the E2 gene, which normally suppresses E6 and E7 expression. HPV integration can occur randomly in the host ...

Researchers from Vanderbilt University Medical Center have demonstrated in a precision-based clinical trial that a magnesium supplement increases gut bacteria in humans that have been shown to ...