Therapeutics that leverage protein degradation as their primary mechanism of action appear to be a validated new therapeutic modality. The current clinical molecules are focused on degrading ...

Adhesion G protein-coupled receptors have a large extracellular region (shown in green and orange) that extends into space outside the cell. Almost 35% of drugs approved by the Food and Drug ...

Over the last decade, antibodies that block extracellular receptors on our immune cells have redefined the treatment approach for certain cancers. Now, all eyes are on how using the opposite approach ...

Researchers headed by a team at the University of Texas at Dallas’ Center for Advanced Pain Studies (CAPS) have made a fundamental discovery about a key mechanism that enables nervous system ...

Explore how engineered extracellular vesicles can enhance antigen-specific regulatory T cells to improve immune response.

A new international study led by Prof. Carmit Levy of the Department of Human Genetics and Biochemistry at the Gray Faculty ...

G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...

A new study shows that the embryo and the uterine lining conduct an active "conversation" from the very earliest stages of ...

Embryos and the uterus exchange molecular signals within the first hour, shaping whether implantation succeeds or fails.

New research combines two powerful imaging techniques to study the complete structure of a common aGPCR, including how its long and complex extracellular region interacts with the transmembrane region ...