C&EN

Small molecule activates key kinase

For decades, scientists have fought cancer by developing small molecules to inhibit kinase enzymes. These enzymes play an important role in a host of cellular processes, including phosphorylation and ...
Devdiscourse

PathGennie enables unbiased simulation of rare molecular events, boosting drug discovery

In the pharmaceutical discovery process, understanding a drug’s residence time—the duration a molecule remains bound to its ...

A short-lived kinase state that's essential for normal cell migration and T-cell function

Scientists at St. Jude Children's Research Hospital have characterized a hidden intermediate state at the center of Src ...

Kanazawa University research: High-speed AFM imaging reveals how brain enzyme forms dodecameric ring structure

Kanazawa University, have captured real-time images showing how a key brain enzyme organizes itself to help memory formation. Their study, published in Nature Communications, reveals that the enzyme ...
AZoLifeSciences on MSN

Elusive kinase state explains how cells achieve efficient signaling

Scientists at St. Jude Children's Research Hospital have characterized a hidden intermediate state at the center of Src ...