The effectiveness of non-clinical drug safety predictions is enhanced by the adoption of three-dimensional (3D) cellular models. 3D bioprinting enables the generation of complex models with spatial ...

The liver has a unique structure, especially at the level of individual cells. Hepatocytes, the main liver cells, release bile into tiny channels called bile canaliculi, which drain into the bile duct ...

Liver disease investigation: When manipulated, this human periportal liver model can mimic several characteristics of biliary fibrosis. It provides a platform to study liver diseases in humans, ...

The liver has a unique structure, especially at the level of individual cells. Hepatocytes, the main liver cells, release bile into tiny channels called bile canaliculi, which drain into the bile duct ...

In a bid to gain further understanding of the etiology and pathogenesis of metabolic dysfunction–associated steatohepatitis (MASH), a team of researchers has created 3D bioprinted liver models. MASH, ...

Human periportal assembloid, showcasing the three key cell types of the liver: portal fibroblasts (magenta), cholangiocytes (green), and hepatocyte nuclei (blue). All cell borders are delineated in ...

As rates of obesity, high blood pressure, type 2 diabetes and sleep apnea increase, cases of advanced chronic liver disease and resulting liver scarring or cirrhosis also are rising. Patients are ...

Periportal assembloid, with the three component cell types visualized: cholangiocytes in pink, portal fibroblasts in green, and hepatocyte nuclei in blue; all cell borders are visualized in white. New ...