All 32 NFL teams are in action in Week 13, as there are three Thanksgiving Day games to dive into and a Black Friday matchup to keep football on all week long.

In Sporting News' picks and predictions for Week 13, the red-hot Texans deal the Colts another loss in a key AFC South showdown while the Shedeur Sanders show in Cleveland screeches to a halt.

In Sporting News' Week 13 picks against the spread, Philadelphia and Buffalo rebound from Week 12 losses while New England and Seattle keep on rolling with more pop at home.

The NFL season is here. Picking NFL games straight up is hard enough, but picking against the spread is even tougher. Here are NFL week 13 picks against the spread. (Spreads are from Tallysight as of Tuesday morning) Green Bay Packers at Detroit Lions (-2.5)

Jason Logan's Bet Now, Bet Later for NFL Week 13 highlights an upcoming low-scoring clash between the Vikings and Seahawks in Seattle.

Few events bring as much excitement to Americans as the NFL season. The 2025 season has many prominent storylines, but which bets should we target in Week 13?