If the 49ers make the playoffs McCaffrey might start to feel the effects of the 400-plus touches he’s on pace for, but that’s a concern for down the road.

Thanks in large part to a stellar defense and a workhorse performance by Christian McCaffrey, the 49ers were able to overcome a bad night by Brock Purdy to defeat Bryce Young and the Panthers on Monday night.

Everything you need to know about the NFL match between Cleveland Browns and San Francisco 49ers, as well as kick-off time and team news

With a win tonight, the 49ers’ odds of making the playoffs move from 83 percent from 89 percent in The Athletic’s NFL Playoff Simulator. With the Rams firmly atop the NFC West (and, now, the entire NFC), San Francisco is overwhelmingly likely to make the playoffs as a wild-card team.

The San Francisco 49ers beat the Carolina Panthers on Monday at Levi's Stadium. How did it affect their standing heading into Week 13?

The Carolina Panthers face the San Francisco 49ers on Monday, Nov. 24, 2025 at Levi’s Stadium in Santa Clara, California.

It wasn't a great performance, but Shedeur Sanders showed better things against the Las Vegas Raiders than what we had seen from Dillon Gabriel in his six starts. Sanders displayed

Is Brandon Aiyuk done in San Francisco? Jay Glazer shared why the wide receiver is on thin ice with the 49ers.

That would be the Los Angeles Rams, who are playing lights out on both sides of the ball. Matt Stafford should be the frontrunner to win MVP, while the Rams defense has allowed the fewest points per game in the league.

Cowboys props hard this Thanksgiving, and a handful of stars are drawing major action. Here are the most popular plays on the board.