BUFFALO, N.Y. -- During normal growth and development, cells in the body communicate with each other through protein receptors on the cell surface. Among the proteins used for this communication are ...

A handful of signalling pathways are repeatedly used to generate the innumerable varied cell types that comprise the bodies of all multicellular organisms. Mounting evidence suggests that the genesis ...

Individuals with one of the most aggressive types of brain tumor have an extremely poor prognosis. Although some patients with GBM respond to treatment with drugs known as RTK inhibitors, most ...

In preclinical proteomics, speed and accuracy are paramount. Increasingly, scientists must capture more data in less time while consuming minimal sample. Given the throughputs required for efficient ...

Metazoans use a handful of highly conserved signaling pathways to create a signaling backbone that governs development. How these few signals have such a versatile action likely depends upon the ...

Mitogen-activated protein kinase (MAPK) networks are essential for the transmission of extracellular signals into appropriate intracellular responses. Prototypical MAPK activation implements a ...

Cellular functions rely on several communications networks that allow cells to rapidly respond to signals affecting the organism. A new study published in the prestigious journal Molecular Cell has ...