Background: Clinical trials are commonly done without blinded outcome assessors despite the risk of bias. We wanted to evaluate the effect of nonblinded outcome assessment on estimated effects in ...
Background The role of mineralocorticoid receptor antagonists (MRAs) in acute myocardial infarction (MI) remains controversial, with conflicting evidence from landmark trials. We aimed to assess the ...
Patients who receive a randomly assigned treatment as part of a randomised controlled trial (RCT) have the same health outcomes as those who receive individualised treatment tailored by their ...
Patients undergoing cardiac surgery often receive red-cell transfusions, along with the associated risks and costs. Early intraoperative normovolemic hemodilution (i.e., acute normovolemic ...
Gilead's ARTISTRY-2 trial shows BIC/LEN is non-inferior to Biktarvy in virologically suppressed adults with HIV, with no new safety signals. ARTISTRY-2's design involved a randomized, double-blind ...
According to a randomized trial, administering a 15% higher dose of levothyroxine with breakfast maintained stable ...
Nature Communications, and Communications Medicine are interested in publishing high-quality clinical research in all areas of medicine. In this call for papers, we invite submissions of papers ...
Background Hypertension is a major cause of premature death worldwide, controlled by only one in five adults. Two trials (Australia and USA) found a single quadpill containing a quarter dosage of four ...
Trials are essential to ruling out what doesn't work, as well as identifying what does Last year, we ran a randomised controlled trial working with ...
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