Cell invasion is a common characteristic of malignant cancers. This plays a central role in tumor metastasis and dissemination, and is largely responsible for deaths related to cancer (1, 2). Tumor ...

Drastic differences in the ways cells behave and respond to drugs are observed when cells are cultured using 3D instead of 2D approaches. These differences are driving the adoption of more advanced ...

An increasing amount of research indicates that more translational and appropriate observations can be made with organoids and micro-tissues in comparison with 2D monolayer cell models. This is most ...

Although used in academic research for several decades, 3D culture models have long been regarded expensive, cumbersome and unnecessary in drug development processes. Technical advances, coupled with ...

Evaluating Anticancer Drugs and Building Tissue and Tumor Co-Culture Models Among Uses The need for new tools and technologies to decrease the cost of drug discovery and reduce animal testing has been ...

Three dimensional (3D) cell culture has been an area of increasing interest and relevance across a wide breadth of fields for some time now. One type of 3D structure generated in vitro are spheroids.

This article includes research findings that are yet to be peer-reviewed. Results are therefore regarded as preliminary and should be interpreted as such. Find out about the role of the peer review ...

In basic and applied biology research, such as investigations of stem cells and drug screening, spheroid cell cultures are valuable, providing a more realistic test environment than the 2D cultures ...

The IncuCyte® Live-Cell Analysis System and IncuCyte® Spheroid Analysis Software Module, provide a robust solution for analyzing the metastatic potential of solid tumors. With integrated, label-free ...