Scientists used the auxin-inducible degron 2 system on CTCF, bringing the novel approach to bear on a fundamental protein. CTCF is a critical protein known to play various roles in key biological ...
Transcription factors are an essential part of gene expression. Some of these proteins are known as master regulators, and they can have an impact on many different biochemical pathways and processes ...
DNA, the long polymer curled up inside our cells, is often described as the instructions for life. But those instructions are stored in DNA’s chemical code, and reading that code requires the ...
It's a common storytelling trope: the stubborn foe who is eventually revealed to be a much-needed friend. Biology has its own ...
St. Jude Children’s Research Hospital scientists have revealed a previously unknown role for CTCF, a pivotal transcription regulator linked to cancer. CTCF is known by biologists for being a master ...
Northwestern Medicine scientists have discovered how molecular "traffic controllers" in cells influence aging and cellular ...
Our DNA contains thousands of genes, and it is critical that the correct genes are expressed in the right places at the proper time. Our cells have a variety of ways to control gene expression, one of ...
The critical role of transcription factors in the regulation of cell function has been undoubtedly established; their tasks in activation, repression, and/or modification of gene expression are ...
CTCF is a transcription factor that has been a research target due to its role in regulating a critical oncogene called MYC. Scientists at St. Jude Children's Research Hospital have found direct ...
to the project ‘Targeting transcription elongation to modify the prostate cancer tumor immune micro-environment’ to the research group Transcriptional Rewiring in Cancer led by Harri Itkonen ...
(Memphis, Tenn.—January 25, 2023) CTCF is a critical protein known to play various roles in key biological processes such as transcription. Scientists at St. Jude Children’s Research Hospital used a ...
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