You can even create custom functions using VBA. Python shines with its vast ecosystem of libraries. It’s an excellent choice for tasks that involve integrating Excel with other systems.

As the Python scripts will run in an isolated container, they will not have access to any local resources, including the local network, computer, files, and a Microsoft 365 authentication token.

Python and Excel can only really talk to each other through limited functions—xl () and =PY ()—that can only return code results, not macros, VBA code, or other data, Microsoft claims.