Tipoff is set for 7 p.m. ET in Cleveland. Cleveland is a 13.5-point road favorite in the latest Cavaliers vs. Pacers odds, while the over/under is 238.5. Before making any Pacers vs. Cavaliers picks, check out the NBA predictions and betting advice from the SportsLine Projection Model.

After a disappointing loss to the Rockets, the Cavaliers host their third NBA Cup game against a division rival.

Group play in the 2025-’26 NBA Cup continues Friday night with a matchup between the Cleveland Cavaliers and Indiana Pacers at Rocket Arena.

Indiana's defense will be dominated by Donovan Mitchell tonight, as our Pacers vs. Cavaliers picks, odds & expert predictions for Friday, November 21 explain.

The Indiana Pacers and Cleveland Cavaliers meet Friday at Rocket Arena in Cleveland, Ohio. Tip-off is scheduled for 7 p.m. ET.

Find the latest odds, spread and score prediction for the Charlotte Hornets vs. Atlanta Hawks NBA game on ESPN to be played on November 23, 2025 on ESPN.

The 2025 NBA Cup will see eight teams play in the upcoming knockout round. We now know who one of them will be. The Toronto Raptors became the first team to clinch the next round of NBA Cup play on Friday,