Joe Serpico shares his top fantasy football plays and favorite picks for Week 13 with all teams in action for a packed Thanksgiving week.

If you had any piece of the New York Giants-Detroit Lions matchup in Week 12 in fantasy football, we hope it was RB Jahmyr Gibbs. In what should go down as the wildest games of the week, the Lions lead back narrowly edged out Colts RB Jonathan Taylor for the best single-game performance of the fantasy season.

Jahmyr Gibbs 55.4 PPR points. Jaxon Smith-Njigba 37.1 points. Hunter Henry 24.5 points. What do these Week 12 scores have in common besides being extraordinarily good point totals? They all occurred against favorable mismatches for those players.

Jahmyr Gibbs and Will Anderson Jr. headlined the performances of former Alabama football players during NFL Week 12.

Bijan Robinson and Jahmyr Gibbs lead UPI senior sports writer Alex Butler's Top-50 fantasy football running back rankings for Week 12 of 2025.

The fantasy football season continues, and with the weather getting colder and harsher around the country, running backs will begin to become much more key for many teams.

The Detroit running back stuffed the stat sheet against the Giants, while a pair of Vikings players fell flat as J.J. McCarthy’s struggles continued.

Welcome back to Fantasy Focus! Daniel Dopp, Field Yates, and Stephania Bell recap Monday Night Football as the 49ers cruise past the Panthers. Who are the must-start lineup locks for Week 13? Plus, waiver wire targets,