Welcome to the Week 12 NFL Running Back Power Rankings! Somehow, we’re about to be done with two-thirds of the 2025 NFL season as December looms. We only had one new addition to the list this week, but we did have some shakeup around the middle of the rankings.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 on a 48-33 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Kansas City Chiefs linebacker Drue Tranquill clobbers Indianapolis Colts running back Jonathan Taylor for a loss of 2 yards.

In the NFL's first game played in Berlin, the Colts took possession with 7:29 left in the extra period, and they did what everyone in the stadium knew they'd do: They gave the ball to Jonathan Taylor.

Indianapolis Colts rusher Jonathan Taylor has vastly impressed over 10 games, racking up 1,139 yards and 15 touchdowns already. The next closest running back (James Cook) is a whopping 219 yards behind. That's roughly two games of average output.

Jonathan Taylor's historic performance on Sunday broke multiple Colts franchise records and placed him in elite NFL company.

Playing quarterback for the Colts isn't the only thing that Daniel Jones does well. When asked about Jonathan Taylor and his teammate's chances of winning league MVP, the Colts' quarterback answered that question while also alluding to his new partnership with FedEx as part of its upcoming Power Move campaign.

The Indianapolis Colts had the Kansas City Chiefs in a bind until late in their matchup Sunday, when they went away from Jonathan Taylor and put the game in Daniel Jones' hands.