RMD Open

High-intensity interval and resistance training programme improves pain and fatigue outcomes in people with systemic sclerosis: a European multicentre randomised con…

Background Pain and fatigue are among the most debilitating symptoms of systemic sclerosis (SSc), severely impairing quality ...
RMD Open

Strengths and limitations of the EULAR definition for difficult-to-treat rheumatoid arthritis

The management of rheumatoid arthritis (RA) has significantly improved, but a substantial number of patients still experience ...
rmdopen.bmj

New guidelines on glucocorticoid-induced adrenal insufficiency: the end of short synacthen test in rheumatology?

Flow chart for GC replacement continuation according to the ESE/ES guidelines .20 21 Conversion factor for cortisol: 1 nmol/L=0.036 µg/dL. GC, glucocorticoid. ES, Endocrine Society; ESE, European ...
rmdopen.bmj

Efficacy and safety of filgotinib in methotrexate-naive patients with rheumatoid arthritis with poor prognostic factors: post hoc analysis of FINCH 3

Objective This analysis evaluated efficacy and safety of filgotinib, a Janus-associated kinase 1-preferential inhibitor, in methotrexate (MTX)-naive patients with rheumatoid arthritis (RA) with ...
rmdopen.bmj

Efficacy and safety of biologics in psoriatic arthritis: a systematic literature review and network meta-analysis

Background Biologic disease-modifying antirheumatic drugs (bDMARDs) and targeted synthetic DMARDs are used in patients with psoriatic arthritis (PsA), but few studies directly compare their clinical ...
rmdopen.bmj

Eosinophilic granulomatosis with polyangiitis exhibits T cell activation and IgG4 immune response in the tissue; comparison with IgG4-related disease

Objective To study the pathophysiological differences of EGPA and IgG 4-related disease (RD) by clarifying their clinical, pathological and immunological features. Methods Clinical and pathological ...
rmdopen.bmj

Optical coherence tomography angiography detects retinal microvascular changes in giant cell arteritis: the potential protective role of aortitis

Objectives To evaluate the diagnostic utility of optical coherence tomography angiography (OCTA)-derived biomarkers in patients with giant cell arteritis (GCA) and to advance the pathophysiological ...
rmdopen.bmj

Risk of extended major adverse cardiovascular event endpoints with tofacitinib versus TNF inhibitors in patients with rheumatoid arthritis: a post hoc analysis of a phase 3b/4 ...

Objectives Compare the risk of extended major adverse cardiovascular (CV) event (MACE) composite outcomes and component events in patients with rheumatoid arthritis (RA) treated with tofacitinib ...
rmdopen.bmj

Cartilage-gut-microbiome axis: a new paradigm for novel therapeutic opportunities in osteoarthritis

DNA of gut microbiota can be found in synovium of osteoarthritis and rheumatoid arthritis. This finding could result from the translocation of still alive bacteria from gut to joints through blood, ...
rmdopen.bmj

Why does the gout attack stop? A roadmap for the immune pathogenesis of gout

Gout is one of the most severe and frequent rheumatic diseases. Clinical manifestations of gout arise from uric acid crystal deposition in the musculoskeletal tissue. At high concentrations of uric ...
rmdopen.bmj

Predictors of a successful glucocorticoid tapering and withdrawal in an inception cohort of patients with lupus nephritis and associations with long-term outcomes and damage ...

Objectives The optimal duration of glucocorticoid (GC) treatment in lupus nephritis (LN) remains unclear. We examined predictors of GC tapering and discontinuation (D/C), flares during tapering and ...