Watch the best plays from San Francisco 49ers running back Christian McCaffery's 142-yard game against the Carolina Panthers ...

Highlights from the Week 12 matchup between the Carolina Panthers and the San Francisco 49ers during the 2025 NFL season.

Watch the top runs from Week 12 of the 2025 NFL season. Highlights from the Week 12 matchup between the Carolina Panthers and ...

Highlights from the Week 12 matchup between the Carolina Panthers and the San Francisco 49ers during the 2025 NFL season.

Watch the best plays from San Francisco 49ers running back Christian McCaffery's 142-yard game against the Carolina Panthers ...

Thanks in large part to a stellar defense and a workhorse performance by Christian McCaffrey, the 49ers were able to overcome ...

San Francisco 49ers kicker Matt Gay connects on a 29-yard field goal to extend the 49ers lead over the Carolina Panthers to ...

San Francisco 49ers running back Christian McCaffrey takes the toss and bursts into the end zone for a 12-yard touchdown run ...

Carolina Panthers kicker Ryan Fitzgerald connects on a 25-yard field goal to trim the San Francisco 49ers lead to 7-3.

San Francisco 49ers quarterbacks hits wide receiver Jauan Jennings for a 10-yard catch and run on third down into the red ...

Carolina Panthers cornerback Mike Jackson leaps up and snatches an incredible interception in the end zone off San Francisco ...

Carolina Panthers quarterback Bryce Young drops 29-yard touchdown dime to wide receiver Tetairoa McMillan to trim the San ...