NFL Upset Predictions and Picks for Week 13 (Can Texans Beat Colts in AFC South Battle?)

Favorites struggled to cover the spread in Week 12 of the NFL season, but they managed to win the majority of games, making it a tough week for betting on under

NFL Week 13 odds: Eagles a TD favorite over Bears, Colts have edge vs. Texans

Week 13 gets underway with a Thanksgiving Day tripleheader, leading off with the Green Bay Packers visiting the Detroit Lions (-2.5) in an NFC North clash. The Kansas City Chiefs (-3) and Dallas Cowboys meet up in the second game of the day, and the Cincinnati Bengals and Baltimore Ravens (-6.5) close out the action.

NFL picks, predictions for Week 13: Texans upset Colts, 49ers shut down Shedeur Sanders-led Browns

In Sporting News' picks and predictions for Week 13, the red-hot Texans deal the Colts another loss in a key AFC South showdown while the Shedeur Sanders show in Cleveland screeches to a halt.

Mahomes comes home to Texas as playoff-chasing Chiefs and Cowboys meet on Thanksgiving

Fresh off beating the Super Bowl champs, the Dallas Cowboys get the runner-up in their annual Thanksgiving home game.
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