No conference championship matchups are set yet, either. Some leagues, like the SEC and Big Ten, appear fairly cut-and-dry, but the Big 12 and ACC remain wide open. Six Big 12 teams are still alive for a spot in their title game, and four ACC teams carry just one conference loss.

The Eastern Illinois Panthers face the No. 10 Alabama Crimson Tide, led by quarterback Ty Simpson, on Saturday, Nov. 22, 2025 at Bryant-Denny Stadium in Tuscaloosa, Ala.

There were several winners and losers in Week 13 of the college football season with Oklahoma helping its playoff hopes and USC seeing its chance end

Allen had a forgettable outing against the Texans, finishing with 24-of-34 completed passes for 253 yards, zero touchdowns and two interceptions. The reigning NFL MVP was also sacked eight times as his pass protection struggled to hold off Houston’s secondary.

The Washington Huskies face the UCLA Bruins in a Big Ten contest on Saturday, Nov. 22, 2025 at the Rose Bowl in Pasadena, Calif.

The Fighting Irish have gone nuclear on overmatched opponents in recent weeks in an attempt to strengthen their playoff case

John Mateer threw two touchdown passes to lead No. 8 Oklahoma to a 17-6 victory over No. 23 Missouri. The win moves Oklahoma closer to a College Football Playoff spot.