In order for the Colts to come away with a much-needed win, here are three keys to accomplishing that. The Colts' downfield ...

The Colts' loss clinched playoff spots for the Bills and Chargers. The 49ers had already clinched their spot in the NFC, and ...

Colts quarterback Philip Rivers had one of the best performances by a 44-year-old in NFL history, and the defense ruined it ...

The San Francisco 49ers have beaten the Indianapolis Colts 48-27 on “Monday Night Football” behind Brock Purdy ’s career-high five touchdown passes. Christian McCaffrey racked up 146 total scrimmage ...

Here are three things to watch for and a prediction for the Indianapolis Colts vs. 49ers Monday Night Football game.