The Colts' loss clinched playoff spots for the Bills and Chargers. The 49ers had already clinched their spot in the NFC, and ...

Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats ...

49ers vs Colts final score, results: Brock Purdy throws five touchdowns, 49ers control destiny after win vs. Colts originally ...

A meeting featuring two of the NFL's best in Christian McCaffrey and Jonathan Taylor will close Week 16 as the 49ers and Colts clash in a matchup with playoff implications.

In order for the Colts to come away with a much-needed win, here are three keys to accomplishing that. The Colts' downfield ...

Now, the model has analyzed Colts vs. 49ers on 'Monday Night Football' and locked in three confident best bets for an NFL SGP ...

Breaking down the best wide receiver targets for the 49ers vs. Colts DraftKings MNF Showdown slate, including usage trends, ...

Here are three things to watch for and a prediction for the Indianapolis Colts vs. 49ers Monday Night Football game.

The SportsLine Projection Model has locked in its top anytime TD scorer picks for San Francisco vs. Indianapolis on Monday ...

The San Francisco 49ers offense is cruising and they were dominant in a win over the Indianapolis Colts. Here are the highlights.