This article was originally published on www.fansided.com as NFL Week 12 picks and predictions, straight-up and ATS: Colts-Chiefs, Vikings-Packers have our attention.

KC Joyner's straight-up confidence picks are 43-13 in the last four weeks. See what he thinks will happen this week.

Let's update our NFL Power Rankings ahead of Week 12. Plus, who is under the most pressure for each team over the rest of the 2025 season?

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 on a 48-33 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

The Broncos have won eight games in a row. The Commanders have lost five in a row. With both teams on a bye, those streaks will next be on the line in prime time. Via Nicki Jhabvala of TheAthletic.com, the Week 13 Broncos-Commanders game will remain on Sunday Night Football.

The Buffalo Bills trail the New England Patriots by 1.5 games in the AFC East standings, and they face even more of an uphill climb thanks to the NFL schedulemakers

Shaun Albin analyzes which defenses (DEF) to sit or start in Week 13 (2025) of the NFL season, and provides his best fantasy football streaming options.