Carolina has a chance to break back into the conversation, and the playoff picture with a win over the 49ers tonight.

For the second week in a row, the 49ers will face an offense in the top five in plays per drive. And while Carolina runs just about the same number of plays per drive as the Cardinals do – Carolina runs 6.4 plays per drive compared to Arizona’s 6.5 – the Panthers score much less frequently than the 49ers’ Week 11 opponent.

The 49ers packaged a second-, third- and fourth-round pick in 2023 and a fifth-rounder in 2024 for McCaffrey from the Panthers.

Dave Canales’s team got a big assist from the Los Angeles Rams on Sunday. The Carolina Panthers will lead the NFC South if they beat the 49ers on Monday night.

The 6-5 Carolina Panthers are tied with the 6-5 Tampa Bay Buccaneers in the win column. They trail by one game by their divisional records (2-1 compared to 2-0) and have an opportunity to take sole possession of the lead in the NFC South with a win over the San Francisco 49ers tonight. Does that make them the best team in the NFC South?

Only two of the NFL's 32 general managers played in the league -- and they took drastically different paths to get there.

The San Francisco 49ers have a big matchup against the Carolina Panthers that will swing the playoff odds in a big way. If the 49ers want to walk out of Week 12 with an 8-4 record and an easy walk into the playoffs, they need a few key names to become big-time players .

The Carolina Panthers can take the NFC South lead with a win on Monday night. The Tampa Bay Buccaneers suffered their third straight loss on Sunday night, opening the door for the Panthers.