The Carolina Panthers and the San Francisco 49ers take the field for NFL Monday Night Football tonight in Week 12. MNF start time, schedule and how to watch.

The Panthers, who face San Francisco on the road Monday night, have played 18 times on ‘MNF.’ Here’s a list of their four biggest wins.

The Carolina Panthers face the San Francisco 49ers on Monday, Nov. 24, 2025 at Levi’s Stadium in Santa Clara, California.

USA Today's NFL experts make their picks for a Week 13 showdown between the Carolina Panthers and Los Angeles Rams

This will surely put them over the top. The Carolina Panthers have announced a pair of moves going into tonight's game with the San Francisco 49ers on ESPN's presentation of Monday Night Football. The Panthers are 6-5 and have a chane to take first place in the NFC South thanks to Tampa's loss to the Los Angeles Rams last night.

If the 49ers make the playoffs McCaffrey might start to feel the effects of the 400-plus touches he’s on pace for, but that’s a concern for down the road.

Teams looking to stay in the mix in their respective divisions clash when the Carolina Panthers battle the San Francisco 49ers on 'Monday Night Football.' Carolina is coming off a 30-27 overtime win over the Atlanta Falcons,

Its a tall ask to look to maintain your playoff hopes when lining up against the Rams, but that is the challenge in front of Bryce Young and the Panthers. Currently the top team in the NFC (and maybe the NFL), the Rams have won six in a row including a 34-7 rout of the Tampa Bay Buccaneers last Sunday night.