If the 49ers make the playoffs McCaffrey might start to feel the effects of the 400-plus touches he’s on pace for, but that’s a concern for down the road.

The San Francisco 49ers beat the Carolina Panthers 20-9 despite Brock Purdy’s 3 INTs. Colin Cowherd discusses the QB’s return from injury and if he is preventing the 49ers from realizing their potential.

The Carolina Panthers face the San Francisco 49ers on Monday, Nov. 24, 2025 at Levi’s Stadium in Santa Clara, California.

The Carolina Panthers (6-5) are monitoring nine players on the injury report, including Bryce Young, as they prepare for a Monday, Nov. 24 matchup against the San Francisco 49ers (7-4) at Levi's Stadium, which starts at 8:15 p.m. ET.

That’s the main question Charlotte Observer sports reporter Alex Zietlow and columnist Scott Fowler tackle in the latest podcast episode of Processing Blue — which was taped mere hours after the Carolina Panthers’ 20-9 loss to the San Francisco 49ers on the West Coast.

The Panthers were considered big underdogs for tonight's game against Santa Clara, and the oddsmakers were right to think so.

Carolina opted for a 57-yard field goal attempt, which would be missed by kicker Ryan Fitzgerald. San Francisco then took over and drained out the game clock. The Panthers (6-6) will head home to host the NFC-leading Los Angeles Rams (9-2) in Week 13.

NFL Week 12 odds, picks, predictions, TV channel, streaming information for Monday Night Football between Carolina Panthers and San Francisco 49ers.

Brock Purdy is back, and the San Francisco 49ers are 7-4 this season after blowing out the Arizona Cardinals in Purdy’s third start of the 2025 season. With his

Carolina is coming off a huge Week 11 win over Atlanta in which quarterback Bryce Young had a career day, passing for 448 yards and three touchdowns in the Panthers' 30-27 overtime victory. Rookie wideout Tetairoa McMillan also set career highs with eight catches for 130 yards and two touchdowns.