Christian McCaffrey turned in another strong performance on Monday night, leading the San Francisco 49ers to a 20-9 victory ...

Brock Purdy's three interceptions did little to stand in the way of another San Francisco 49ers victory as they took care of ...

Three first-half interceptions turned Purdy into a dink-and-dunker for the rest of the game. The 49ers need the good Purdy ...

Christian McCaffrey dominated his former Carolina Panthers team as the San Francisco 49ers secured a 20-9 victory on "Monday ...

Brock Purdy threw a touchdown in the first quarter, Christian McCaffrey ran for a touchdown in the third quarter and the ...

San Francisco 49ers star running back Christian McCaffrey faced his former team for the first time since they traded him ...

Fans can listen to Monday Night Football live with SiriusXM on channel 88, NFL Radio, for the national broadcast.

Christian McCaffrey had a big night in his first game against Carolina since the Panthers traded him to San Francisco three ...

Is Christian McCaffrey the running back to target for Monday Night Football, or will Rico Dowdle stay hot in Week 12?

With a win tonight, the 49ers’ odds of making the playoffs move from 83 percent from 89 percent in The Athletic’s NFL Playoff ...

SportsLine's AI Model has simulated 49ers vs. Panthers on 'Monday Night Football' and revealed an NFL SGP that pays over 6-1 ...

Odds, game bets, prop plays and analysis to help you bet Monday night's Carolina Panthers-San Francisco 49ers game.