The Cleveland Browns return home after a 24-10 win in Vegas, while the San Francisco 49ers beat the Panthers on Monday Night Football for their second straight

If the 49ers make the playoffs McCaffrey might start to feel the effects of the 400-plus touches he’s on pace for, but that’s a concern for down the road.

San Francisco 49ers wide receiver Jauan Jennings didn't stutter when he talked about Tre'von Moehrig's cheap shot to his nuts.

Earlier this season, Detroit Lions safety Brian Branch received a one-game suspension for striking Kansas City Chiefs receiver JuJu Smith-Schuster after a game. Branch appealed the decision, but league officer Jordy Nelson upheld the punishment; similar penalties could be considered here as well.

Jauan Jennings responded to a "cheap shot" from Tre'von Moehrig by throwing an open-handed right cross to the Panthers safety's face after the final whistle Monday night.

NFL Week 13 odds, picks, predictions, TV channel, streaming information for the Sunday football game between San Francisco 49ers and Cleveland Browns.

Christian McCaffrey gained 142 yards from scrimmage and scored a touchdown in his first game against Carolina since he was traded away three years ago, leading the San Francisco 49ers to a 20-9 victory over the Panthers on Monday night.

The San Francisco 49ers will take on the Carolina Panthers on Monday, but they'll be without two players and could have two more miss the game.

The Panthers were considered big underdogs for tonight's game against Santa Clara, and the oddsmakers were right to think so.

Brock Purdy insists his toe is “fine” after a three-interception win, leaving the 49ers to decide whether execution is the real concern.