The advent of amyloid-β (Aβ) and tau PET imaging has revolutionized Alzheimer disease (AD) research, enabling in vivo ...

Radiotheranostics refers to dual diagnostic–therapeutic capacity that allows for precision medicine at an unprecedented level, reducing collateral toxicity and improving patient outcomes ([1][1]). In ...

The coronavirus disease 2019 (COVID-19) pandemic underscored the need for the development of tools that can visualize immune system activity in the context of viral inflammation. Although [18F]FDG PET ...

In recent years, several radiotracers targeting the prostate-specific membrane antigen (PSMA) have been introduced. Some of them have had a high clinical impact on the treatment of patients with ...

Good-manufacturing-practice–grade precursor DOTA-Siglec-9 was obtained from ABX Advanced Biomedical Compounds GmbH. All other reagents were purchased from commercial suppliers and were either ...

Journal of Nuclear Medicine November 2025, jnumed.125.270703; DOI: https://doi.org/10.2967/jnumed.125.270703 ...

Journal of Nuclear Medicine November 2025, jnumed.125.270568; DOI: https://doi.org/10.2967/jnumed.125.270568 ...

Prostate cancer is the most common cancer diagnosis in men in the United States and a leading cause of cancer-related morbidity and mortality (1). It can exist along a wide spectrum of aggressiveness ...

The results are presented as median and interquartile range (IQR) for continuous variables and as number and percentage for categoric variables. Kaplan–Meier analysis was used to estimate overall ...

Pharmacokinetics of radiopharmaceuticals (e.g., radioimmunotherapy agents) are assumed to follow first-order kinetics and are, therefore, approximated by the sum of discrete rates (1–3). However, the ...

The poly (adenosine diphosphate–ribose)polymerase (PARP) family of enzymes is an important factor in the cellular DNA damage response and has gained much attention for its role in many diseases, ...

See an invited perspective on this article on page 466. We believe that the PSMA-RADS system is most useful for the categorization of lesions outside the prostate. The reason for that is twofold.