The NFL's upcoming lineup of games is rife with questions. But there's little question that the Chiefs are approaching must-win territory in Week 12.

Sam Farmer makes his picks and score predictions for Week 12 of the NFL season, with Patrick Mahomes and the Chiefs winning at home over the Colts.

It’s Week 12! A few teams have placed themselves firmly in the playoff picture, while a few players are separating themselves in the MVP race. One player we won’t see this week is Ja’Marr Chase (though Conor Orr says players shouldn’t be suspended for spitting ).

We won't quite be treated to the same host of elite matchups in NFL Week 12 that we were last week, the slate still offers a ton of fun, especially given the na

Texans (+5.5) over Bills. Buffalo's defense is reeling at the moment, allowing 30 or more points in back-to-back games. The Bills' run defense has been abysmal, surrendering 5.4 yards per carry (second most in the NFL). That could result in a strong day for the Texans on the ground, which could help tip the scales in favor of an upset.

Kansas City Chiefs quarterback Patrick Mahomes (15, left) and Indianapolis Colts QB Daniel Jones (17, right) face off Sunday in NFL Week 12’s Game of the Week.

The Cowboys' offense is cooking, and the Eagles' is not, while Patrick Mahomes and the Chiefs are staring down a three-game losing streak.

The New York Giants visit the Detroit Lions this Sunday at Ford Field, and here are five storylines to watch in Week 12.