The Arizona Cardinals made some NFL history in their Week 12 loss to the Jacksonville Jaguars. Teams with a +4 turnover differential were previously 50-0 dating back to 2021, though Arizona stopped that streak after falling in their overtime loss to the Jaguars.

The Jaguars are 5-4-1 against the spread, while the Cardinals are 5-5 ATS. Arizona has the 14th-best offense and 21st best defense, while Jacksonville has the 19th-best offense and14th-best defense. Jaguars vs. Cardinals score prediction: Jaguars 26, Cardinals 23

What's the Arizona Cardinals vs Jacksonville Jaguars score? Follow our live score updates for latest news, highlights, analysis from NFL Week 12 game.

The Arizona Cardinals are under the microscope for three plays that happened late in their loss against the Jacksonville Jaguars.

Expert recap and game analysis of the Jacksonville Jaguars vs. Arizona Cardinals NFL game from November 23, 2025 on ESPN.

USA Today's NFL experts make their picks for a Week 12 showdown between the Arizona Cardinals and Jacksonville Jaguars

What channel is Jacksonville Jaguars vs Arizona Cardinals game on today? How to watch NFL Week 12 football game on TV, streaming on Sunday, Nov. 23.

Arizona Cardinals quarterback Jacoby Brissett is dealing with an injury in the second half of the Week 12 game against the Jacksonville Jaguars.

Arizona Cardinals vs Jacksonville Jaguars picks, predictions, odds, win probabilities for NFL Week 12 Sunday game on Nov. 23. Who will win game today?

GLENDALE -- In Walter Nolen's fourth NFL game, he managed to score quite the impressive touchdown to level things at 7-7 between the Arizona Cardinals and Jacksonville Jaguars. In the first quarter, Jaguars QB Trevor Lawrence was hit while dropping back to pass by Cardinals safety Jalen Thompson - popping the ball loose.