Mike Florio and Chris Simms run through their best bets for Week 13 of the NFL season, including the San Francisco 49ers and ...

The 49ers fly to Cleveland on a short week, as the Browns are set to start Shedeur Sanders for the second straight game, but ...

Matt Maiocco addresses the latest 49ers overreactions after San Francisco's Week 12 win over the Carolina Panthers.

On this episode of "49ers Talk," co-hosts Matt Maiocco and Jennifer Lee Chan reflect on the blockbuster trade that brought ...

Brandon Aiyuk‘s rollercoaster 49ers tenure took another wild turn Friday. The 49ers voided the future money on Aiyuk’s ...

49ers head coach Kyle Shanahan, during an appearance on NBC Sports 49ers Talk, had some very high praise for Pearsall amid ...

Shedeur Sanders will make the second start of his career as the Cleveland Browns (3-8) host Brock Purdy and the San Francisco ...

The San Francisco 49ers earned a key win to close out Week 12. San Francisco beat the Carolina Panthers 20-9 on Monday Night ...

San Francisco 49ers linebacker Curtis Robinson is bracing for a full-circle moment when he makes his first NFL start vs. the ...

The Cleveland Browns return home after a 24-10 win in Vegas, while the San Francisco 49ers beat the Panthers on Monday Night ...