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Predictions, picks and odds for NFL Week 12 game

Who is favored to win in Indianapolis Colts vs. Kansas City Chiefs? NFL predictions, picks in Week 12

The AFC South-leading Indianapolis Colts (8-2) visit the Kansas City Chiefs (5-5) in NFL Week 12 action.

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· 1d · on MSN

NFL Week 12 odds, predictions, expert picks: Can Cowboys upset Eagles? Will Colts take down Chiefs?

Chiefs vs. Colts prediction, pick, odds for Sunday's NFL Week 12 game

Chiefs vs. Colts 2025 Prediction, Odds, Picks - Nov 23

The Kansas City Chiefs (5-5) are favored by 3.5 points against the Indianapolis Colts (8-2) on November 23, 2025, starting at 1 p.m. ET, airing on CBS.

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Chiefs vs. Colts best bets, picks and odds | Week 12 2025

Chiefs playoff odds: What a loss to the Colts would mean for their postseason chances