Carolina has a chance to break back into the conversation, and the playoff picture with a win over the 49ers tonight.

Multiple players have been ruled out for NFL Week 12 as the Panthers face the 49ers. Learn how the injuries impact expert predictions.

The Carolina Panthers have a really difficult matchup tonight on the road in prime time against the San Francisco 49ers. But this is not an unwinnable matchup (

The Carolina Panthers and the San Francisco 49ers meet for Monday Night Football in Santa Clara, California. Kickoff is scheduled for 8:15 p.m. ET.

DraftKings has the Panthers team total listed at a respectable 20.5 points, while the 49ers, who have finally got the band back together on offense, are coming in with a projection of 29 total points. For the third time this season, the trio of McCaffrey, Brock Purdy, and George Kittle will share the field. The 49ers are 2-0 when all three suit up.

The San Francisco 49ers have a big matchup against the Carolina Panthers that will swing the playoff odds in a big way. If the 49ers want to walk out of Week 12 with an 8-4 record and an easy walk into the playoffs, they need a few key names to become big-time players .

Teams looking to stay in the mix in their respective divisions clash when the Carolina Panthers battle the San Francisco 49ers on 'Monday Night Football.' Carolina is coming off a 30-27 overtime win over the Atlanta Falcons,

The 49ers packaged a second-, third- and fourth-round pick in 2023 and a fifth-rounder in 2024 for McCaffrey from the Panthers.

Carolina will be missing multiple starters on defense as well as a big absence in the middle of their offensive line.