The Carolina Panthers and the San Francisco 49ers take the field for NFL Monday Night Football tonight in Week 12. MNF start time, schedule and how to watch.

This will surely put them over the top. The Carolina Panthers have announced a pair of moves going into tonight's game with the San Francisco 49ers on ESPN's presentation of Monday Night Football. The Panthers are 6-5 and have a chane to take first place in the NFC South thanks to Tampa's loss to the Los Angeles Rams last night.

The Carolina Panthers made their first prime-time appearance in an NFL regular-season game since Nov. 9, 2023, on Monday night with an opportunity to take sole possession of the lead in the NFC South.

NFL Week 13 odds, picks, predictions, TV channel, streaming information for Sunday football game between the Los Angeles Rams and Carolina Panthers.

The Carolina Panthers face the San Francisco 49ers on Monday, Nov. 24, 2025 at Levi’s Stadium in Santa Clara, California.

Catch Bryce Young and the Panthers (6-5) against Brock Purdy and the 49ers (7-4) at 8:15 p.m. ET on ESPN with streaming options available.

The Panthers, who face San Francisco on the road Monday night, have played 18 times on ‘MNF.’ Here’s a list of their four biggest wins.

Our favorite Panthers vs. 49ers prop picks for Monday Night Football Week 12 are highlighted by star tight end George Kittle.

The San Francisco 49ers picked up a huge win in the NFC wild-card race on Monday night over the Carolina Panthers.

The San Francisco 49ers are back at Levi’s Stadium in Week 12 of the NFL season with a “Monday Night Football” matchup set against the Carolina Panthers.

In the second half, Purdy and Co. settled down, extending their lead with an 80-yard touchdown drive in the early stages of the third quarter. Christian McCaffrey was the one to find the end zone at that juncture, scoring from 12 yards out against his former team as he squared off against them for the first time since being traded in 2022.