The Iowa Hawkeyes (6-4) square off against a conference opponent when they host the Michigan State Spartans (3-7) on Saturday, Nov. 22, 2025 at Kinnick Stadium in a Big Ten showdown. Date: Nov. 22

When Iowa wins, they win big. That's exactly why ESPN Analytics gives them an 89.4% chance to beat MSU. Iowa dominated Rutgers in the second half and blew past both Wisconsin and Minnesota, with only the Golden Gophers game taking place at home. It'd be shocking if their game against the Spartans wasn't a repeat of October 25 vs. Minnesota.

Preview the Nov. 22 matchup between the Iowa Hawkeyes and Michigan State Spartans with predictions, odds, over/under, spread, betting lines and more.

A look at Iowa Hawkeyes football’s opportunity vs Michigan State to deliver a lasting home image on offense with a QB that has helped move the needle.

The losing, quite literally, may never end for Michigan State football, at least this year. Ever since the Spartans started 3-0, they've lost eight in a row, al

Learn which TV channel or how to live stream the Iowa Hawkeyes vs. Michigan State Spartans game, Saturday, Nov. 22.