The Kansas City Chiefs have a massive game in Week 12. They take on the upstart Indianapolis Colts. The Colts aren't far off the AFC's No. 1 seed, while the Chiefs are 5-5 and in at least slight danger of missing the playoffs. Kansas City had injury doubts during the week, too, led by speedy wide receiver Xavier Worthy.

Learn which TV channel or how to live stream the NFL Week 12 Kansas City Chiefs and Indianapolis Colts game, Sunday, Nov. 23.

You've seen the model's best bets for Indianapolis Colts vs. Kansas City Chiefs. Now, get against the spread, total and money-line picks for every Week 12 NFL game here, all from the model that's simulated every game 10,000 times.

The Colts are coming off their bye week and the Chiefs have lost two straight. Kansas City is 0-5 in one-possession games.

The Kansas City Chiefs now sit at 5-5 following their Week 11 loss to the Denver Broncos on Sunday. Here's where the Chiefs sit in the NFL power rankings of experts going into Week 12.

Mike Florio is picking the Chiefs to win by a field goal, while Chris Simms has the Colts winning by a field goal. "Will the real Chiefs finally stand up?" Florio wrote. Of ESPN's eight NFL analysts making predictions, six of them are taking the Chiefs. Pete Prisco is picking the Chiefs to win by a score of 26-20.

The Kansas City Chiefs have their backs against the wall now. After their loss to the Denver Broncos, they've dropped to just 5-5 on the 2025 NFL season. 12 win

Jones was added to the Colts' Week 12 injury report after being limited Thursday with what was initially described as a calf injury. Per Stephen Holder of ESPN.com, upon further evaluation it was deemed that the QB was managing a fibula issue,