NFL Week 13 odds, picks, predictions, TV channel, streaming information for the Sunday football game between San Francisco 49ers and Cleveland Browns.

The San Francisco 49ers beat the Carolina Panthers on Monday at Levi's Stadium. How did it affect their standing heading into Week 13?

Aiyuk wouldn’t be the first player to rehab away from the team facility. In 2024, the 49ers led the NFL in adjusted games lost. Outside of 2023, the Niners have been in the top-10 in adjusted games lost in every season since 2020. It’s understandable why any player would want to rehab elsewhere based on the results.

After Monday's game, a 20-9 49ers win, Jennings chased down Moehrig and struck him with a closed fist. Jennings' actions were retaliatory, with a replay later revealing that Moehrig landed an uppercut to Jennings' groin during the game.

The Panthers are wishing they played better against the Niners, but the loss didn't affect their placement in NFL.com writer Eric Edholm's power rankings. The Panthers are staying at No. 19 despite falling to the 49ers.

The Carolina Panthers face the San Francisco 49ers on Monday, Nov. 24, 2025 at Levi’s Stadium in Santa Clara, California.

The San Francisco 49ers overcame that Thanksgiving Week generosity and toppled the Carolina Panthers 20-9, thanks largely to defensive heroics that included two interceptions by safety Ji’Ayir Brown.

Week 12 of the NFL season is in the books. Per usual, John Breech of CBS Sports handed out his grades when it came to each club’s performance. The last of the 14 games played took place on Monday night, when the San Francisco 49ers hosted the improving Carolina Panthers.