Gut

Acute upper gastrointestinal bleeding in the UK: 2022 audit update

Background Acute upper gastrointestinal bleeding (AUGIB) is a common medical emergency with evolving demographics and ...
Gut

FOXM1 inhibition reduces IL-13-induced epithelial remodelling and inflammation in eosinophilic oesophagitis

Background Eosinophilic oesophagitis (EoE) is a chronic allergic disease characterised by oesophageal epithelial remodelling, barrier dysfunction and inflammation. The transcription factor forkhead ...
Gut

Gut microbiome in IBD: past, present and the future

IBD has become a global disease in the 21st century that shifts through four epidemiological stages. Alterations in the gut ...
Gut

Thrombospondin-2: a promising but unproven biomarker for MASH

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disorder worldwide, reflecting the growing prevalence of obesity and type 2 diabetes. Some patients ...
gut.bmj

Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification

Dr L Lundell, Department of Surgery, Sahlgrenska University Hospital, S-413 45 Göteborg, Sweden. BACKGROUND Endoscopic oesophageal changes are diagnostically helpful and identify patients exposed to ...
gut.bmj

The window hypothesis: haemodynamic and non-haemodynamic effects of β-blockers improve survival of patients with cirrhosis during a window in the disease

1 Department of Gastroenterology, Hvidovre University Hospital, Faculty of Health Sciences, Copenhagen University, Hvidovre, Copenhagen, Denmark 2 Department of Internal Medicine, Copenhagen ...
gut.bmj

Inflammatory bowel disease linked to accelerated cognitive decline in individuals with dementia: a nationwide cohort study

A recent study by Erkert et al identified a new role for Alzheimer’s disease (AD)-associated presenilins as key molecules involved in maintaining intestinal epithelial function, barrier integrity and ...
gut.bmj

Association of dietary macronutrient composition and non-alcoholic fatty liver disease in an ageing population: the Rotterdam Study

Objective A healthy lifestyle is the first-line treatment in non-alcoholic fatty liver disease (NAFLD), but specific dietary recommendations are lacking. Therefore, we aimed to determine whether ...
gut.bmj

STEM CELL IN GASTROINTESTINAL STRUCTURE AND NEOPLASTIC DEVELOPMENT

1 Histopathology Unit, Cancer Research UK, Lincoln’s Inn Fields, London, UK 2 Histopathology Unit, Cancer Research UK, Lincoln’s Inn Fields, London, UK and Molecular Pathology Centre, Institute of ...
gut.bmj

Tumour-associated macrophages-derived CXCL8 determines immune evasion through autonomous PD-L1 expression in gastric cancer

Objective Our previous studies have identified CXCL8 as the crucial chemokine responsible for gastric cancer metastasis mediated by loss of RACK1. However, the regulatory effect of CXCL8 on immune ...
gut.bmj

Short exposure of oesophageal mucosa to bile acids, both in acidic and weakly acidic conditions, can impair mucosal integrity and provoke dilated intercellular spaces

Department of Pathology, University Hospital Gasthuisberg, Catholic University Leuven, Belgium Dr D Sifrim, Faculty of Medicine, KU Leuven, Lab G-I Physiopathology, O & N Gasthuisberg 1, Herestraat 49 ...
gut.bmj

Development and validation of the Nancy histological index for UC

2 Inserm U954, Genetic Nutrition and Exposure to Environmental Risks (NGERE), University of Lorraine, Vandoeuvre- lès-Nancy, France Correspondence to Professor Laurent Peyrin-Biroulet, Inserm U954 and ...