Journal of Nuclear Medicine

SIRPα Immuno-PET Provides a Pan-Myeloid View of Immune Activity During COVID-19

The coronavirus disease 2019 (COVID-19) pandemic underscored the need for the development of tools that can visualize immune system activity in the context of viral inflammation. Although [18F]FDG PET ...
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Nuclear Imaging Strategies to Evaluate Cytokine Production in Autoimmune, Inflammatory, and Neoplastic Diseases: A Review of Current Preclinical Research

Cytokines are small proteins that directly regulate immune cell proliferation and signaling. An improved understanding of cytokine expression in specific microenvironments provides critical insights ...
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PSMA PET Evaluation with a Deep Learning Platform Compared with a Standard Image Viewer and Histopathology

Journal of Nuclear Medicine October 2025, jnumed.125.270242; DOI: https://doi.org/10.2967/jnumed.125.270242 ...
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OpenDose3D: A Free, Open-Source Clinical Dosimetry Software for Patient-Specific Dosimetry

Journal of Nuclear Medicine September 2025, jnumed.125.269539; DOI: https://doi.org/10.2967/jnumed.125.269539 ...
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Clinical Validation of Deep Learning for Image Restoration of Ultra-Low-Count

Journal of Nuclear Medicine August 2025, jnumed.124.269234; DOI: https://doi.org/10.2967/jnumed.124.269234 ...
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CD24 as a Novel Radiopharmaceutical Target for Hepatocellular Carcinoma

Journal of Nuclear Medicine July 2025, jnumed.125.270167; DOI: https://doi.org/10.2967/jnumed.125.270167 ...
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225 Ac α-Pretargeted Radioimmunotherapy of Human Epidermal Growth Factor Receptor 2–Expressing Breast Cancer

Radioimmunotherapy using 225Ac, a highly cytotoxic α-particle emitter, has potential for treating advanced breast cancer, especially human epidermal growth factor receptor 2 (HER2)–positive cases. We ...
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GPC3-targeted immunoPET allows for early detection of HCC: a pilot clinical study

Journal of Nuclear Medicine June 2025, 66 (supplement 1) 252173; ...
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A Phase I/II Study of

Journal of Nuclear Medicine April 2025, jnumed.124.269064; DOI: https://doi.org/10.2967/jnumed.124.269064 ...
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First-in-Human Phase 0 Study of AB001, a Prostate-Specific Membrane Antigen–Targeted

Journal of Nuclear Medicine March 2025, jnumed.124.269299; DOI: https://doi.org/10.2967/jnumed.124.269299 ...
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uPAR Immuno-PET in Pancreatic Cancer, Aging, and Chemotherapy-Induced Senescence

Identifying cancer therapy resistance is a key time-saving tool for physicians. Part of chemotherapy resistance includes senescence, a persistent state without cell division or cell death. Chemically ...
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Intrapatient Intermetastatic Heterogeneity Determined by Triple-Tracer PET Imaging in mCRPC Patients and Correlation to Survival: The 3TMPO Cohort Study

Journal of Nuclear Medicine September 2024, jnumed.124.268020; DOI: https://doi.org/10.2967/jnumed.124.268020 ...