USC still has a rivalry game against UCLA next week and a bowl game sometime in December, but the meaningful portion of the Trojans’ 2025 season came to a close when Oregon put the finishing touches on a 42-27 win in Autzen Stadium and knocked USC out of the College Football Playoff picture.

The ESPN "College GameDay" crew likes Oregon's chance of defeating USC Saturday in the final regular-season home game at Autzen Stadium

As expected, there was no change around the top-dozen of the Coaches Poll top 25 college football rankings, but losses by lower-placed teams allowed some moveme

The Ducks are 10.5-point favorites in the latest Oregon vs. USC odds, while the over/under for total points scored is 59.5, down four points from the opener. Before making any USC vs. Oregon picks, check out the college football predictions from the SportsLine Projection Model .

Week 13 was relatively quiet, as a handful of SEC teams hosted FCS opponents and cruised to victory. That said, losses by both USC and Missouri are sure to shake up the rankings.

The No. 15 USC Trojans' aspirations of reaching the College Football Playoff came to a close on Saturday, as they fell 42-27 to the No. 7 Oregon Ducks in Eugene